Cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid gastric administration during the pregestational and gestational periods does not influence the follicular endowment of the progeny

Fetal programming suggests that maternal stimulation and nutrition during the period of fetal development can program progeny. Conjugated linoleic acid (CLA), an isomer acid, has been characterized in several aspects, but few studies have performed on its involvement reproduction programming. The aim this study was to evaluate F1, F2 F3 progeny female mice supplemented with CLA pregestational gestational periods respect biometric reproductive parameters, as well ovarian morphophysiology. F1 mothers exhibited stable weight gain, while showed no effects (P=0.0187 P=0.0245, respectively). A reduction Lee's Index observed both generations at second post-weaning evaluation week animals treated (P=0.0100 P=0.0078, generation increase anogenital index sexes (P= 0.0114 P<0.0001, male administration did not affect any following their progeny: follicle mobilization (P>0.05), number (P>0.05) integrated density lipid content oocytes included antral follicles (P>0.05). This evaluated use found it regarding murine performance, suggesting supplement be used safely.